Comparison of 8-Hydroxy Deoxyguanosine Level in the Saliva between the Patients with Recurrent Aphthous Stomatitis and Healthy Individuals

Hydroxydeoxyguanosine (8-OHdG) is a product of DNA damage. Considering the role of oxidative stress in the etiopathogenesis of recurrent aphthous stomatitis, the present study aimed to evaluate the DNA damage caused by oxidative stress in these patients. This case-control study was conducted on 30 patients with recurrent aphthous stomatitis and 30 healthy subjects. The subjects were matched in terms of age and gender. The inclusion criteria for enrollment were the absence of systemic diseases, no drug use, no tobacco and alcohol use, and no use of antioxidant supplements for the past 3 months. The inclusion criterion for recruitment in the study groups was the presence of a recurrent aphthous ulcer for a minimum of three times per year. Unstimulated saliva sampling was performed. Data were analyzed by t-student. No significant difference was observed between the patients with recurrent aphthous stomatitis and healthy subjects regarding the level of 8-OHdG (P=0.427)