Synthesis of 5-3-bromo phenyl and 5-3 choloro phenyl- 1,3,4 oxadiazol-2 eyl piridin-2-eyl methanol and evaluation of antibacterial activity

Oxadiazole derivatives that are highly bioavailable, for example, can be a good alternative to antimicrobials and may have a better effect on the same drugs than those of the host. The aim of this study was to evaluate the antibacterial properties of oxadiazole synthesized derivatives and compare it with common antibacterial drugs on some pathogenic bacteria. Material and Methods: In this study in a single process reaction of N- isocyanimino triphenyiphosphorane, carboxylic acid derivatives and 2-pyridinecarbalhyde in acetonitrile solvent, new derivatives of Oxadiazole were attained. The structures of synthesis compounds were surveyed and established by the use of IR, H-NMR and C-NMR spectrometer. The synthesized compounds were tested for their antimicrobial activity against Entrococcus faecalis PTCC 1788 and Proteus vulgaris PTCC 1861 by disc diffusion method and Minimal Inhibitory Concentration (MIC) and determination of Minimal Bactericidal Concentration (MBC). The results that show all the synthesized compounds had antibacterial activity against E. faecalis, but they did not have that much influence on P. vulgaris. This is important that the synthesis of oxadiazole compounds has antibacterial nature which is a single-process reaction and it was accomplished with high efficiency and in a very short time.