Effect of florfenicol following bath and oral administration on hematological and biochemical parameters in common carp, Cyprinus carpio

Florfenicol is used in aquaculture to treat bacterial infections. In this study, effect of florfenicol on some hematological and biochemical parameters was investigated. One hundred eighty healthy common carp with 50±10 g average weigh were divided at 3 groups (bath, oral, control). Bath and oral groups received 5 mg/l and 10 mg/kg of drug respectively, for 10 consecutive days and control group don’t receive any drug. Then, blood samples for hematological and biochemical estimation were collected at 1, 7 and 14 days after experimental period. Results showed that treatment of fish with bath and oral florfenicol administration for 10 days, significantly depressed hemoglobin, erythrocyte counts, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration compared with control group (p<0.05). The mean corpuscular volume and activity of AST, ALT and ALP enzymes were enhanced significantly with respect to the control group (p<0.05). According to the results of this research, it seems that the ten day period of florfenicol administration in common carp can decrease most of hematological parameters and increase activity of serum enzymes.