The Effect of Coenzyme Q10 on the Nervous Protection and Movement Disorders in Model of Mice Parkinson's Disease induced by 6-HDOP

Parkinson's disease is one of the most common types of neurodegenerative diseases characterized by motor disorders such as slow motion, lack of movement, muscle stiffness, resting vibrations, and facial masks. The main cause of the disease is the destruction of dopaminergic neurons in the compact part of the substantia nigra in the middle cerebrum, which is associated with a decrease in dopamine concentration at the terminals of corpus striatum. This study was conducted to investigate the effect of coenzyme Q10 on the 6-hydroxydopamine-induced animal model (PD). To create a mock-up model of Parkinson's disease, 6-HDOP poison five μg/kg of mice body weight was injected into the Substantia nigra nucleus in adult NMRI mice. The accuracy of the Parkinson's model in mice was confirmed using catalepsy and apomorphine-induced rotation tests. Immediately after surgery, the Parkinsonian mice were treated with water (solvent Q10) with doses of 25, 50, and 100 Coenzyme Q10 for two weeks and then were subjected to behavioural tests and the neurons of the substantia nigra nucleus was counted. The results indicate that treatment with Q10 significantly reduced the immobility time and Catalepsy, increased motor activity and decreased apomorphine rotation, indicating the protective effects of Coenzyme Q10 against Parkinson's Disease Damage.