Effect of Alcoholic Extract of Ziziphora tenuior L on Blood Glucose and Lipid Profiles in Streptozotocin-Induced Diabetic Rats

Diabetes is a common metabolic disorder associated with an increased risk of cardiovascular disease, disability, and mortality. The present study was conducted to evaluate the effects of alcoholic extract of Ziziphora tenuior L (ziziphora) plant on blood glucose and fat profiles in streptozotocin-induced diabetic rats. In this study, 40 male wistar rats were divided into five groups: control, diabetic control, experimental group receiving dose 50, 75 and 100 mg/kg of hydoalcholic exctract of ziziphora. Diabetes was induced by intraperitoneal injection of streptozotocin (50 mg/kg). After 28 days, the extract was gavaged, blood samples were collected and biochemical analysis was performed to determine the levels of glucose, insulin and lipid profiles in the serum. The alcoholic extract of ziziphora consumed three in all doses significantly increased body weight, insulin and decreased blood glucose but did not have a significant effect on cholesterol, HDL and LDL. Oral administration of the hydroalcholic extract of the ziziphora probably leads to a decrease in blood glucose in type 1 diabetic rats by increasing insulin secretion.