Polyvinyl chloride (PVC) exerts toxic effects via the formation of oxidative stress on the brain. Antioxidants such as Vitamin E (Vit E) can affect free radicals.
This study was conducted to decrease damage and oxidative stress against PVC products in rats’ brain by vitamin E.
In the current study, we used 24 male Wistar rats in four groups (N = 6 rats per group) as the control, Vit E, PVC, PVC plus Vit E. We orally administered vitamin E and PVC for 40 days. Then the rats were anesthetized and the brain was removed and transferred to a temperature of -70ºC in order to measure lipid peroxidation.
our results revealed that oral administration of PVC decreased catalase and total antioxidant capacity levels, and increased malondialdehyde in PVC exposed rats. Vitamin E improved spatial memories by enhancing neurogenesis in the brain.
Exposure to PVC can produce oxidative stress enzymes and make brain damage. Vitamin E, as an antioxidant, can decrease the toxic effects of PVC and protect the brain.
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