Role of optical coherence tomography in the early detection of macular thinning in rheumatoid arthritis patients with chloroquine retinopathy
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
Chloroquine and hydroxychloroquine are drugs that are primarily used for the treatment of malaria and are alsorecommended for treating connective tissue disorders, autoimmune diseases, and some dermatological and inflammatory diseases.
Treatment with these drugs has potential risk for the development of retinopathy, clinically characterized by bilateral pigment changes
in the macula, as one serious ocular complication. The aim of this research was to evaluate the parafoveal and perifoveal macular
retinal thickness, as central foveal thickness in adult patients with rheumatoid arthritis (RA) on chloroquine therapy using optical
coherence tomography (OCT).
Materials and Methods
In this cross‑sectional study, 56 RA patients (56 eyes) were included andexamined. All patients were treated with chloroquine (tablets resochin or delagil) at a dose of 250 mg/day without treatment with
steroids and other immunosuppressive drugs. Patients were divided into two groups, namely, Group I patients ‑ no visible changes
in the macula (26 patients) and Group II patients‑ with visible changes in the macula (30 patients). The central fovea thickness and
parafoveal and perifoveal retinal thickness in all quadrants were measured by OCT and compared in both groups.
Results
Thereare a significantly higher number of eyes without thinning of the macula in Group I patients than in Group II (P < 0.001) patients.
There are a higher number of patients with recorded parafoveal thinning in Group II patients, especially in the inferior, nasal, and
temporal sectors, respectively (P < 0.05).
Conclusion
Maculopathy is the main side effect of chloroquine therapy in RA patientsthat can be detected by OCT in the early stages of the macular involvement.
Keywords:
Language:
English
Published:
Journal of Research in Medical Sciences, Volume:24 Issue: 6, Jun 2019
Page:
2
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