A retrospective institutional study of histopathologic pattern of Oral Squamous Cell Carcinoma (OSCC) in Tehran, Iran during 2006‑2015

Despite the available data on demographic information of oral squamous cell carcinoma (OSCC), the changing trend of
histopathologic pattern of OSCC has not conducted yet, in Iran. The aim was to investigate the pattern of histopathologic features of
OSCC in Iran by analyzing the patients referred to Cancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences,
Tehran, Iran, during 2006-2015. The study was a retrospective institutional study. The pathology records
with the diagnosis of OSCC were retrieved from Iran National Tumor Bank, Cancer Biology Research Center, Cancer Institute of
Iran, Tehran University of Medical Sciences, Tehran, Iran, during 2006-2015. The demographic characteristics and histopathologic
features were recorded and analyzed for possible trend. Descriptive analysis was used for statistical interpretation. The data
showed an increasing number of moderately and poorly differentiated OSCC. Accordingly, higher increasing rate in tumor size and
vascular, perineural invasion was detected. On the basis of histopathologic features, moderately differentiated OSCC
with increasing rate of tumor size and vascular, perineural invasion was indicated in recent decade. Based on the findings, lower
differentiation potentially is compatible with worsen prognosis.