Predicting Alzheimer's Disease using Soft Computing Feature selection algorithms and Based on rs-fMRI and sMRI

Alzheimer’s disease (AD), a progressive, irreversible neurodegenerative disorder, occurs most frequently in older adults and gradually destroys regions of the brain that are responsible for memory, thinking, learning, and behavior. In this paper, AD prediction is investigated based on rs-fMRI and sMRI analysis. Three feature selection algorithms based on soft computing method has been proposed to classify MCI-C from MCI-NC through training SVM. This is the first study used to integrate rs-fMRI and sMRI for AD prediction. The results refer to the significant brain areas (functional and structural) impaired in AD. Furthermore, NBS method on brain functional parcellations has been utilized for separating MCI-C from MCI-NC and detecting the discriminative ability networks for AD prediction.