Fabrication of Bilayer Nanocellulosic Aerogel Scaffold and Evaluation of Its Properties for Skin Tissue engineering

This study aimed to fabricate the bilayer scaffold containing nanocellulose/poly (vinyl) alcohol (CNF/PVA) to evaluate its potential use as a mimic for skin tissue engineering. A continuous process of layer addition with two different concentrations of polymers by freeze-drying technique was used. FE-SEM analysis indicated that the obtained scaffolds had interconnected porosity and pore size, which increased in lower concentration of polymers. The scaffolds were also characterized by water uptake, mechanical properties and MTT assay. Lower concentration of polymers increased water uptake and decreased mechanical strength. The MTT assay results showed that these nanofibrous scaffolds meet the requirement as a biodegradable material for skin repair.