Effect of Eight Weeks of High-Intensity Interval Training on the Level of Plasma and Adipose Tissue Zinc Alpha 2 Glycoprotein (ZAG) in High Fat Diet-Induced Obese Male Rats

Zinc-Alpha 2-Glycoprotein (ZAG) has recently been implicated in the regulation of adipose tissue metabolism due to its negative association with obesity. The purpose of the present study was to investigate the effect of eight weeks of high intensity interval training on the level of ZAG in plasma and adipose tissue in obese male rats. 

In the current experimental study, 21 male rats were divided into three groups of sham control (healthy), control (obese), and interval training (obese with training). The training group received eight weeks of training sessions each with 5-12 repetitions of high intensity training for 15-30 seconds at the speed of 27-34 meters per second on a treadmill followed by one minute of active rest. Then, 24 hours after the training sessions, blood and body fat samples were obtained to measure ZAG levels. The data was analyzed using one-way ANOVA and Tukey’s post hock test at the significance level of 0.05 (P<0.05).

There were significant differences between the sham control and obese groups with respect to ZAG contents in plasma and adipose tissue, which was lower in obese groups (p<0.001). The eight-week high intensity interval training significantly increased the amount of secreted ZAG in adipose tissue compared to the control group (p<0.001).

It seems that HIIT training increased ZAG content in the adipose tissue of the male obese rats.
This can reduce the amount of adipose tissue through lipolysis of the adipose tissue.