Effect of Aerobic Training with Two Different Intensities on Some Angiogenesis Factors in Renal Tissue of Diabetic Rats

Background and The angiogenesis inhibitors and the pro angiogenesis factors are enhanced in diabetic patients; especially those are involved in exercise. The purpose of this study was to compare the effects of endurance training with moderate and high intensities on some angiogenesis factors in renal tissue of diabetic rats. Sixty male rats were divided into 6 groups (n=10 per group): Sedentary control (SC), Sedentary Diabetic (SD), Diabetic Moderate intensity training (DMT), Healthy Moderate intensity training (MT), Diabetic High intensity training (DHT) and Healthy High intensity training (HT). The exercise protocol performed 8 weeks of moderate and high intensity aerobic training, 5 sessions per week and 60 minutes per session. Eight weeks of moderate and high intensity aerobic training significantly reduced blood glucose in diabetic rats, but this decrease was higher in the DMT group. Also, eight weeks of moderate and high intensity aerobic training in both diabetic groups significantly increased VEGF (P = 0.002 and P = 0.000, respectively) compared to the SD, but for VEGFR1 was observed only between DHT compared to SD (P = 0.007). compared to high intensity aerobic training, moderate aerobic training results in a decrease in the levels of glucose and an increase in VEGF.