Variations in some of hepatic parameters following exposure to 67gallium and 131 iodine in male rat

The liver is an organ at risk in radiotherapy of thoracic and abdominal tumors. In this study was investigated the alteration in liver functional tests during radiotherapy with gallium 67 and iodine 131. Materials&

60 male wistar rats were divided into 3 groups: the control without treatment, the experimental groups 1 and 2 received 0.1Mci 131 iodine through oral gavage 0.3Mci 67Gallium with intraperitoneal injection respectively. 48 hours after injection, the level of serum aspartate aminotransferase, alanine aminotransferase and albumin were checked.

The results showed that level of serum aspartate aminotransferase in 131 iodine group and alanine aminotransferase and albumin significant increased in 131 iodine and 67Gallium than control group.

Regarding liver sensitivity during radiation therapy and elevated serum levels of these enzymes, liver function tests are useful as biomarkers for the detection of raditherapy effects.