The Effect of Varicocelectomy on Semen Analysis and Serum Levels of Inhibin B

Article Type:
Research/Original Article (دارای رتبه معتبر)

Varicocele means dilation and torsion of spermatic veins. About 15%-40% of infer- tile men suffer from Varicocele. It seems that 70% of secondary infertility in men occurs due to Varicocele. Varicocele is the most common surgical cause for male infertility. Varicocelectomy is considered as the best treatment method for patients with Varicocele that increases 30%-50% of the postoperative fertility rate. The purpose of this study was to investigate the effect of Vari- cocelectomy on inhibin B and use this marker to predict infertility in men.


In this study, all infertile patients in any age that were candidate for Varicocelectomy and hospitalized in Imam Hospital in Urmia were included. Exclusion criteria were defined as or- chitis, trauma, diabetes, radiotherapy, chemotherapy and coitus complications. Sperm analysis (SA) was conducted three times for patients and then serum levels of FSH, LH, T, inhibin B, SA were measured before surgery and also six months after surgery. Furthermore, during the hospi- talization and infertility period, testes were examined before surgery in terms of consistency and size.


The mean ± SEM (standard error median) age of 40 patients was 28.4±5.14 (range: 18- 40) years old. Mean size of the testes and mean sperm density and serum levels of LH.FSH re- mained the same. However, mean sperm motility, serum levels of T and inhibin B were statistically significant after the Varicocelectomy (p-value=0.005). A significant relationship was found be- tween serum levels of inhibin B and infertility; however, there was no significant relationship be- tween sperm count and serum levels of LH, FSH and T. Varicocelectomy can improve sperm mo- tility and increase Inhibin B in patients and so improves spermatogenesis parameters and it may be one of the causes of fertility in patients.


The results of this study indicate that sperm motility and increase in inhibin B after Varicocelectomy can improve spermatogenesis parameters. Serum levels of FSH, T, LH and sperm morphology and also grade of Varicocele, patient age, and testis size have no effect on spermato- genesis and fertility after Varicocelectomy.

Men's health journal, Volume:3 Issue: 1, Winter 2019
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 1,390,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
In order to view content subscription is required

Personal subscription
Subscribe for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!