The Effect of Fatty Liver with or without Hepatomegaly on the Renal Artery Resistance

Fatty liver can cause vascular damage due to metabolic syndrome. On the other hand, the onset of fatty liver disease is expected to lead to a change in the level of GFR or possibly the resistance of the renal artery. According to the above, we aimed to study the effect of fatty liver with or without hepatomegaly on the resistance of the renal artery by designing this study.

In this cross-sectional study, patients after diagnosis of fatty liver by ultrasound (hyper echogenic hepatomegaly with dorsal hypo echogenicity) and elevated liver enzymes enrolled the study. Also, as patients in the case group, healthy subjects with no liver problems that were matched for age and sex were included. Subsequently, patients were asked about demographic information and anthropometric information, and then the patients underwent sonography of B mode and Doppler. Renal length, kidney thickness, liver size and spleen size were also calculated by abdominal sonography. In this study, the renal artery resistance index was obtained based on the formula RI= [VmaxSystole-VminDiastole]/Vmax-Systole. All patients' information was entered into SPSS software and analyzed. Ethics code: IR.TBZMED.REC.1396.906

In this study,The mean age of all participants in the study was 42±11 years. Right kidney RI was 0.61±0.05 in the fatty liver group and 0.59±0.11 in the normal group (P=0.155). The RI value of the left kidney was 0.62±0.05 in the fatty liver group and 0.59±0.0.03 in the healthy subjects group. This difference was not statistically significant (P=0.389). Correlation coefficient between age and right renal RI was 0.249 (P=0.027) and this factor between age and left kidney RI was 0.325 (P=0.003). Both relationships were statistically significant.

There is no meaningful relationship between renal RI and fatty liver, and the use of renal RI in early diagnosis of kidney disease in patients with fatty liver is not beneficial.