Camel Milk Antioxidant Activity in Rats Infected with Shigella dysenteriae

Shigella infections lead to secretion of pre-inflammatory cytokines which lead to release of Reactive oxygen species. These radicals induce oxidative stress by peroxidation of lipids and DNA. Antioxidant compounds can reduce injuries resulting from bacterial infections. Camel milk play an important role in reducing oxidative stress. Therefore, protective effects of camel milk against Shigella dysenteriae were evaluated in rats.

Rats (120± 20g) were divided into 5 groups. Group infected with Shigella dysenteriae (1.5×108 CFU/ML), Group infected with Shigella dysenteriae and treated by 33ml/kg of camel milk, Group infected with Shigella dysenteriae and treated by 5mg/kg of Sefixim antibiotic, group treated by of camel milk, group infusive control. After finishing treatment period, the animals were anaesthetized and their tissues from intestine, liver and spleen were separated and the activity level of enzymes, superoxide dismutase and catalase, was evaluated in these tissues.

In this text, the activity level of superoxide dismutase and catalase decreased in the tissues infected with Shigella dysenteriae. This decrease was raised up to a normal level following. Treatment by camel milk or antibiotic and camel milk

These results indicate that camel milk capable reduce of dysfunction in the liver, spleen, intestine and the synergistic effect with antibiotics and can be used to treat shigellosis, strengthen the immune system and antioxidant.