The Effects of Three Different Doses of Sufentanil on Changes in Blood Pressure and Heart Rate after Laryngoscopy and Intubation, and Comparison with the Control Group

Hemodynamic disorders is a common and serious complication during endotracheal intubation with various suggested preventive methods; but there is no consensus. The aim of this study was to determine the effect of three different doses of sufentanil on heart rate and blood pressure changes after laryngoscopy and endotracheal intubation, and to compare it with the control group.

In a double-blind clinical trial study, 128 patients undergoing surgery with general anesthesia were randomly divided into 4 groups of 32. In the first group, as the control group, the drug was not injected, and the other three groups received 0.1, 0.2, and 0.3 µg/kg sufentanil, respectively, which was injected before laryngoscopy. Hemodynamic parameters were determined at 0, 1, 3, 5, and 10 minutes after laryngoscopy, and were compared between the four groups.

The trend of blood pressure changes during laryngoscopy was significantly different between the four groups; but the changes in heart rate and oxygen saturation were not different between the groups. Changes in the level of hemodynamic parameters showed that the group receiving 0.3 µg/kg sufentanil had higher stability during the laryngoscopy.

Dosage of 0.3 µg/kg sufentanil appears to be associated with favorable hemodynamic stability of patients during laryngoscopy and endotracheal tube insertion.