Clinicopathological Characteristics of Oral Pyogenic Granuloma in Isfahan School of Dentistry

 Oral pyogenic granuloma (PG) is a benign lesion that can occur due to chronic mild irritation, a traumatic surgical procedure, hormonal changes, certain medications, after bone marrow grafting, a response to a graft, etc. Two histopathological type of PG are lobular and non-lobular. This aimed to assess and compare the clinical, microscopic, and etiologic factors in the two type of PG.

 In this cross-sectional descriptive/analytical study, 214 samples of PG were selected from the Archives of the Pathology Department, Isfahan Dental School. Demographic, clinical, and microscopic data were collected by reviewing the files and slides. Data were analyzed with SPSS 24, using descriptive statistics, chi-squared test, Mann-Whitney test, Fisher‘s exact test, and t-test (α = 0.05).

 There were 47 lobular cases, with 167 non-lobular samples. Lesion sizes (p value = 0.035), location of lesions (p value < 0.001), mean vascular density (p value < 0.001), concentration of large endothelial cells (p value < 0.001), edema (p value = 0.007), inflammatory infiltration intensity (p value < 0.001), and vascular canalization (p value = 0.005) were significantly different between the two groups.

 The present study showed that some parameters between the two microscopic types of pyogenic granuloma were different significantly, accounting for the clinicopathological differences between two groups; this warrants further studies.