Assessment of Changes in Autophagy Factors in Time Courses of Acute Exhaustive Endurance Exercise in Tibialis Anterior Skeletal Muscle of BALB/c Mice

Autophagy has been introduced as a protective mechanisms in cell in recent years. Regarding to the changes induced in autophagy factors following an acute physical exercise. The purpose of this study was to investigate the changes in autophagy factors in time courses of acute exhaustive endurance exercise in Tibialis Anterior skeletal muscle of BALB/c mice.

Regarding the purpose of the study, 12 BALB/c mice were divided into two groups of exercise and control. Subjects were anatomized immediately and 12 hours after the end of the exercise session. The Real Time-PCR method was used to determine the expression of autophagy factors.

Independent t-test showed significant increases in autophagy activation immediately after exercise and significant decreases 12 hours following acute exhaustive endurance exercise (P≤0.05).

  Our results proposed that significant increases induced in autophagy factors immediately after acute exhaustive exercise. Possible correlations between autophagy activation and changes in oxidative stress, some immunological factors and metabolic responses could be some of mechanisms of autophagy activation following acute exercise.