Interleukin-6 Increased in Sera of Dialysis Failure Patients with Severe Heart Failure

Kidney failure is one of the most important health problems. The average life expectancy of dialysis patients is 3 to 5 years and . tThehe most common cause of death is cardiovascular events. Common risk factors for heart disease such as diabetes and hypertension alone do not justify the high risk of such events in these patients. The role of inflammation and the increase of inflammatory factors have been discussed more than other causes. Interleukin-6 has the strongest prognostic power to predict death in dialysis patients and is the best component of the expression of underlying inflammation. The purpose of this the present study was to determine the association of interleukin-6 with echocardiographic findings in dialysis patients.

In this the current descriptive study, 52 adult patients (19 to 80 years old) with ESRD undergoing dialysis were selected from available samples. Data was provided with a checklist containing the variables studied including age, gender, duration of onset and as well as underlying cause of kidney failure and history of heart disease. Interleukin 6 was determined by using ELISA technique. Echocardiographic findings, including Ejection Fraction, inter ventricular septum diameter, and left ventricular end diastolic diameters, were all determined by one cardiologist with using a fixed echocardiography device. Data were analyzed using SPSS, software  version 23.

Dialysis patients with severe heart failure had higher levels of IL-6 than other dialysis patients (P-value= 0.044). There was no significant relationship between serum interleukin 6 with inter ventricular septum diameter and left ventricular diastolic diameter.

It seems that, IL-6, as an important factor, indicates severe heart failure and high mortality in dialysis patients. There is no relationship between the level of interleukin 6 and the ventricular septum and left ventricular diastolic diameter.