The effect of the aerobic continues and high-intensity interval training on IRE1 expression and its correlation with insulin resistance index of liver tissue in rats with type 2 diabetes mellitus

The purpose of this study was to determine effect of the aerobic continuous versus high-intensity, interval training on IRE1 expression and its correlation with insulin resistance index of liver tissue in rats with type 2 diabetes mellitus.

Twenty-four heads of male Wistar rats (weight 160-180 g) after 7 months of high-fructose-containing diet were divided into three groups of control, aerobic continuous and intermittent exercise. They practiced the protocol in five days a week for two months. Blood samples were collected 24 h after the last training session, and liver tissue was immediately extracted. Pearson correlation, one-way ANOVA and Tukey post hoc test were used to analyze the data.

Both exercise models reduced IRE1 gene expression in the liver of type 2 diabetic rats compared to the control group (P=0.005), but no significant differences were observed between the two exercise groups (P=0.877). There was a correlation between the expression of IRE1 gene and insulin resistance index such that decrease of IRE1 gene expression resulted in decrease of insulin resistance index (r=-0.667, p=0.003).

The results of this research show that both HIIT and continuous aerobic training can be used to improve the studied parameters in type 2 diabetic subjects.