The Effect of High Running on Serum Adropine and Insulin Resistance Index in Adolescent Obese Boys

Studies have shown that adropine is associated with metabolic homeostasis. The aim of the present study was to investigate the effect of high intensity running on serum adropine level and insulin resistance in obese adolescent boys.

In this semi-experimental study, 25 obese adolescents (mean age 13.40±0.71 years; weight 86.05±8.37 kg) were randomly selected and divided into two groups of running and control. The training group, running at 60-75% of maximal heart rate, performed four sessions per week for 10 weeks. Data were analyzed by independent and dependent t-test at the P<0.05.

The results of this study showed that weight (P=0.001) and body fat percentage (P=0.020) were significantly decreased in the high intensity running post-test compared to the pre-test and the control group. Serum adropine levels were significantly increased in the high-intensity running group compared to the pre-test group and the control group (P=0.003). There was a significant correlation between changes in adropine and changes in body weight, body fat percentage and HOMA-IR (P<0.05).

High-intensity running is associated with the higher adropine levels and as a result, improve indices of metabolic.