Effects of aerobic training and vitamin D on HSP70 gene expression in lung tissue of rats exposed to hydrogen peroxide

The purpose of present study was to investigate the effect of aerobic training and vitamin D on the gene expression of HSP70 in the lung tissue of rats exposed to oxygenated water.

In this experimental study, 30 male male Wistar rats were randomly divided into five groups of six each: oxygenated water, oxygenated water plus vitamin D, oxygenated water plus aerobic training, and oxygenated water plus aerobic training plus vitamin D. The groups underwent the respective interventions for 8 weeks. HSP70 gene expression were measured by real time and PCR.

The aerobic training and vitamin D a lonely caused significant decrease in gene expression of HSP70 compared to oxygenated water (P<0.05) but the interaction effect of aerobic training and vitamin D interactiondid not significant.

It seems that aerobic training and vitamin D induce improve of oxidative stress and inflammation in lung tissue.