The Effect of 8 Weeks of Resistance and Aerobic Interval Training on Levels of GLP-1, NRG-1 and IL-33 in Type 2 Diabetic Women

Considering the importance of glycemic balance adjustment in preventing cardiovascular complications of diabetes mellitus, regulation and control of blood glucose and insulin resistance is a very important issue. Including the protective factors that contrast with high blood glucose damage, can interoduce glucagon-like peptides (GLP-1), Neuregulin-1 (NRG-1), and interleukin-33 (IL-33) that this factor can be affected by exercise. Therefore, the purpose of this study was to investigate the effect of 8 weeks of resistance and aerobic interval training on levels of GLP-1, NRG-1 and IL-33 in type 2 diabetic women. 30 diabetic women (51.9 ± 5.9 years) were randomly devided into 3 groups (n=10 in each group), resistance training, aerobic interval training and volunteer control. Aerobic interval training was performed with intensity of 50-75% MHR and resistance training performed with intensity of 30-75% 1RM, 3 sessions per week for 8 weeks. The values of GLP-1, NRG-1 and IL-33 were measured by ELISA kit. For data, analysis used ANCOVA (P<0.05). The results of this study showed that resistance training compared to control group significantly increased (P = 0.007) the GLP-1. Aerobic (P = 0.037) and resistance training (P = 0.001) compared to the control group and resistance training compared to aerobic training (P = 0.008) significantly increased IL-33. NRG-1 changes were not significant in the two training groups. It seems that resistance training with positive regulation of GLP-1 and IL-33 has a better effect on glycemic control, blood glucose and ultimately improving cardiovascular conditions in type 2 diabetic women.