Correlation of Serum Resistin Level with Insulin Resistance and Metabolic Parameters in Patients with Type 2 Diabetes and Prediabetes

Resistin an adipocytokines secreted by adipocytes, is associated with insulin resistance and increases in obesity, cardiovascular disease and other inflammatory diseases. The aim of this study was to investigate the relationship between resistin levels, metabolic variables, and insulin resistance in patients with prediabetes / diabetes in an Iranian population.

This study was conducted on 75 patients with fasting plasma glucose (FPG)≥ 100 mg/dl in prediabet ic/ diabetic group and 75 participants with FPG less than 100 mg/dl as control group. Plasma levels of resistin and insulin were measured by ELISA kit and other variables were determined by standard methods. Statistical analysis was performed using SPSS software, version 19.

Resistin levels, body mass index, triglyceride, cholesterol, FPG and insulin resistance were significantly higher in patients with pre-diabetes / diabetes compared with controls (P-value <0.05). Serum resistin level was positively correlated with body mass index, FPG and insulin resistance (P-value <0.05). Reverse correlations were found between resistin and HDL (P-value <0.05).

Higher levels of resistin in patients with type 2 diabetes / pre-diabetes in our study and significant association of resistin with glucose, insulin resistance, and BMI, indicate the pathophysiological role of this adipokin in the development of type 2 diabetes.