Evaluation of Different Doses of Melatonin Effect on Post-Operation Pain Score in Patients Who Underwent Caesarian Section with Spinal Anesthesia, a Double Blind Clinical Trial

Due to the importance of pain control in the postoperative period, prescribing painkillers reduces postoperative complications by improving patientschr('39') pain. This study evaluated the effect of different doses of Melatonin on postoperative pain in cesarean section patients under spinal anesthesia.

In this clinical trial, 150 pregnant women enrolled the study who were candidates for elective cesarean section referring to Imam Ali (AS) Hospital in Zahedan in 1398. Patients were randomly assigned to 3 groups of melatonin 1.5 and 3 mg two hours before spinal and control groups. The severity of the pain and the need for analgesics were assessed in groups. In the end, data analyzed using SPSS software ver. Twenty-three by ANOVA and chi-square statistical tests.

The mean age of the patients was 26.3 ± 4.7 years. The results showed that with increasing melatonin dose, patientschr('39') pain decreased during recovery, 6 and 12 hours after that (P < 0.05). The first painkiller administration time was significantly higher in patients receiving Melatonin than the control group (P < 0.05). There was no significant difference in postoperative adverse effect frequencies between groups (P < 0.05).

Melatonin in different doses can be used for pain control and increasing the painlessness duration in the cesarean section.