Differential diagnosis of tuberculosis, sarcoidosis, and anthraco-sis by CD8, CD3, and CD4 levels by flow-cytometry

Determination of a desirable diagnostic tests is an issue of im-portance especially to differentiate between tuberculosis) TB(, sarcoidosis, and anthracosis. The purpose of the present study was to determine the differen-tial diagnosis of tuberculosis, sarcoidosis and anthracosis with CD8, CD3, and CD4 by flow-cytometry.

In this descriptive cross-sectional comparative sur-vey, 40 consecutive patients attending to Masih Daneshvari Hospital in Tehran were enrolled and CD4/CD8 ratio, CD8, CD3, and CD4 were determined by flow-cytometry and compared across patients with three diseases including tu-berculosis, sarcoidosis, and anthracosis.

The results demonstrated that CD4 was significantly higher in anthra-cosis cases (P<0.007) and the CD8 was significantly higher in patients with TB (P<0.008).

It was attained ultimately that CD4 and CD8 levels could be a desirable diagnostic markers for anthracosis and TB, respectively