Study of protective effects of raspberry fruit extract (Rubus fruticosus L.) on the antioxidant function in male diabetic rats induced with STZ

The aim of this study was to Evaluation of protective effects of raspberry fruit extract (Rubus fruticosus L.) on the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzymes and serum level of malondialdehyde (MDA) and Total antioxidant capacity (TAC) in male diabetic rats induced with streptozotocin. In this laboratory experimental study Diabetic rats were induced by diabetes induction by intraperitoneal injection of STZ. Raspberry fruit was extracted with the usual method. Rats were randomly divided into five healthy (control), diabetic (DM) and DM + doses (50, 100, 200) mg / kg. After intraperitoneal injection of raspberry fruit extract for 4 weeks, the activity of superoxide dismutase enzymes (SOD) and glutathione peroxidase (GPx) and serum level of malondialdehyde (MDA) and Total antioxidant capacity (TAC) was determined and the data were statically analyzed using ANOVA. SOD and GPx activity and Serum levels of TAC was significantly decreased in DM group compared to other groups (P<0.05). While after treatment, the activity of all two SOD and GPx enzymes and Serum levels of TAC were significantly increased (P<0.05). Serum levels of MDA was significantly increased in the DM group (P<0.05) and significantly decreased after treatment with the extract (P<0.05). Our results indicate that raspberry fruit extract with increased antioxidant activity and capacity, and inhibiting the production of MDA in the serum level of STZ-induced diabetes, induces improved antioxidant activity.