An aggressive verrucous carcinoma of the palate with rare presentations and recurrence: A case report and literature review

Oral verrucous carcinoma (OVC) is a rare malignant tumor with a complex etiology. This tumor is more prevalent in men and buccal mucosa is the most common site of OVC. Altogether, OVC has a relatively good prognosis.

In this case report, a rare case of a 64-year-old female with history of consuming opium and involvement of hard palate was reported. Because of the high recurrence rate, a more aggressive approach was considered for second surgery. After 18 months of follow up, the patient was in good health condition and no sign of recurrence was noted.

Precancerous lesions may develop into OVC; Differentiation of OVC from other oral lesions is challenging for oral pathologists due to different origins of the lesion. In case of immediate relapse or recurrence after surgery, surgeons are forced to use more aggressive approaches to eliminate the lesion.