Predicting factors of serum lactate in patients under general anesthesia with propofol during spine surgery

Increased serum lactate is seen during surgery due to tissue hypoxia. There have been reports of propofol infusion syndrome due to long-term use of this drug, especially in intensive care patients. This study was conducted to evaluate the factors affecting serum lactate levels in patients under general anesthesia with propofol in spine surgery.

In a cross-sectional study, 70 patients undergoing elective spine surgery (laminectomy) in the operating room of Rasoul Akram Hospital in 1398 were included in the study. Propofol was used to maintain anesthesia. Mean arterial blood pressure, heart rate, pH, arterial bicarbonate, arterial dioxide pressure, arterial base excess and serum lactate were measured and recorded during surgery and at the end of surgery. Parameters determining serum lactate levels were examined in a logistic regression model.

Logistic multivariate regression analysis showed that ASA, hemoglobin, blood transfusion and mean arterial blood pressure were significant predictors of high serum lactate in patients (P <0.05). The variables of hemoglobin, blood transfusion and arterial bicarbonate of patients are statistically significant in predicting high open arterial access in patients (P <0.05).

Hemoglobin, blood transfusion and mean arterial blood pressure predict the development of high serum lactate in patients under general anesthesia with propofol.