Furin, CTRP-12, TNF-α and Lipid Profile Changes during 8 Weeks of Aerobic Interval and Resistance Training in Women with Type 2 Diabetes

Strategies of furin control, inflammatory factors and also increased CTRP-12 are effective to prevent and treat metabolic disorders associated with obesity and diabetes. One of the effective strategies is training. Therefore, the aim of this study was to investigate the effect of 8 weeks of aerobic interval and resistance training on levels of furin, CTRP-12, TNF-α and lipid profile in type 2 diabetic women. 30 diabetic women (51.9 ± 5.09 years) were randomly divided into two groups of training (aerobic interval and resistance) and one control group. The training groups performed aerobic interval and resistance training for 8 weeks and 3 sessions per week. Furin, CTRP-12, TNF-α, and lipid profile were measured using ELISA kit.  Data were analyzed by ANCOVA at the significance level (P<0.05). The results of ANCOVA showed a significant difference between the study groups after 8 weeks of intervention in the furin (P=0.046, F=3.472) and CTRP-12 (P=0.016, F=4.893). The results of LSD post hoc test showed that resistance training significantly decreased furin (P=0.020) and CTRP-12 (P=0.004) compared with the control group. However, the significance of TNF-a was not confirmed (P=0.055, F=3.245). It seems that changes of CTRP-12 with resistance training are more affected by furin and less affected by TNF-α inflammatory adipokine in diabetic patients. This pathway controls insulin resistance as well.