The effect of aerobic and resistance training with different dose of Methadone on fibrinogen and lipid profile in addicted men

Effective use of medications as methadone with exercise training can facilitate the development of healthy. The aim of this study was to compare the effect of different training with methadone on fibrinogen and lipid profile of addicted men.

90 addicted men are treated in prison (36.8 ± 4.3yrs) were randomly divided into six groups (n=15): control, Narcotics Anonymous(NA), aerobic training + methadone, aerobic training + methadone reduction, resistance training + methadone, Resistance training + methadone reduction. Experimental groups performed training for 12 weeks, three sessions in week. Aerobic training consisted of 4 to 8 sets, 3-min at 80–90 % maximum heart rate (HRmax) on a cycle ergometer. Resistance training performed with 8 to 12 repetitions, 3 sets and 70-85% one repetition maximum(1RM). Data were analyzed by SPSS software and Multiple analysis of variance (MANOVA) and Tukey post hoc test at the significant level (P≤0.05).

The high-density lipoproteins (HDL) level of blood in the training groups was significantly increased (P≤00001) compared to the control group. Also, low-density lipoproteins (LDL, P≤0.005), Triglycerides (TG, P≤0/008), Total Cholesterol (P≤0/014 and fibrinogen (P≤00001) levels were significantly reduced in the training groups compared to the control group. Also, the aerobic training groups had a greater effect of all the measured variables than the resistance training.

regular exercise, especially aerobic and resistance exercises with a reduction in methadone has a favorable effect on inflammatory factors and ultimately the health of addicted people