The effect of aerobic training and Spirulina supplementation on Resistin and C - reactive protein in women with type 2 diabetes with overweight

Inflammatory factors are known as an important mechanism for the development of type 2 diabetes and cardiovascular disease. Therefore, this study aimed to investigate the effect of aerobic training and Spirulina supplementation on Resistin and CRP in women with type 2 diabetes with overweight.

In this semi-experimental study, 40 women with type 2 diabetes and overweight with average body mass index of 29.7±3.33, were randomly assigned in groups of aerobic training+Spirulina, aerobic+placebo, Spirulina and placebo. The aerobic training program included 6 weeks with intensity of 60-72% of the maximum heart rate. The groups receiving supplementation, daily received three capsules 500 mg of Spirulina. Blood samples were collected in the pre and posttest phases. Data analysis was performed using one-way ANOVA and t-test Using SPSS software.

Serum levels of Resistin in the Spirulina group (P=0.03) and serum levels of CRP in the of aerobic-Spirulina and aerobic groups (P=0.02) showed a significant decrease from the pre-test to the post-test phase. Also, there was a significant difference in serum levels of CRP between all three experimental groups compared to the control group (P≤ 0.05).

The results of this study showed that combined aerobic training with Spirulina supplementation have a positive effect on cardiovascular inflammatory factors of women with type 2 diabetes and because of its anti-inflammatory effect, it can reduce the risk of heart disease.