The effect of exercise pre-conditioning with intense intermittent training on MDA, SOD and GPX of cardiac tissue following induction of acute myocardial infarction in male rats

The aim of the present study was to investigate the effect of exercise pre-conditioning with intense intermittent exercise on MDA, SOD and GPx enzymes of myocardial infarction following acute myocardial infarction in male rats.

Based on this goal, 20 8-week-old male Wistar rats (mean weight 224.41 ± 5.1 g) were divided into 4 groups: control, training, stroke and stroke-training. The training groups performed two weeks of intense intermittent training in four sections. The first part of three days of training, two sessions per day and each session consisting of 4 intense two-minute intervals at a speed of 35 to 40 meters per minute . In the second part, two training days, two training sessions each day containing 4 cycles of intense activity of 2 minutes and 3 cycles of active rest of 2 minutes. The third part, in three training days, included 5 intense cycles and 4 active rest cycles. The fourth part consisted of two training days with the same intensity as the third part but with an increase in the frequency of activity and active rest in each session.

One-way analysis of variance test showed that two weeks of intense intermittent training, although reducing the heart attack area of rats, however, it did not cause significant changes in MDA, SOD and GPx enzymes following acute myocardial infarction between stroke-exercise and stroke groups.

Intense intermittent exercise reduces heart damage in myocardial infarction, and this reduction occurs independently of changes in oxidative and antioxidant factors.