Silver Nanoparticles and Structural Changes in Brain Tissue of Male rats Following Aerobic and Anaerobic Preconditioning

The use of nanoparticles is increasing and can cause neurotoxicity and brain tissue changes. On the other hand, pre-conditioning improves neuronal protections. Therefore, the aim of this study was to investigate the structural changes in brain tissue following Nano silver injections following the two protocols. 30 male Wistar rats were divided in 6 groups of healthy control, nano silver, aerobic protocol, anaerobic protocol, nano silver + aerobic protocol, nano silver + anaerobic protocol. Intraperitoneal injection of nano silver after 10 weeks of aerobic and anaerobic treatments was performed 10% of each rat's body weight in 5 turns. After 48 hours of the last infusion, the rats were indifferent and sampled. The samples were then photographed and stained with Hematoxylin-Eosin and were studied by optical microscopy. The results of this study indicated that pre-conditioning had a significant effect on weight (P = 0.045) and distance traveled in progressive endurance test (P = 0.000). Nanosilver also caused inflammation (P = 0.000) and neuron degeneration (P = 0.000) of brain tissue in nanosilver rats. However, in the training groups, inflammation (P = 0.001) and degeneration (P = 0.001) were reduced, although there was no significant difference between the protocols in degeneration (P = 0.875) and inflammation (P = 0.928). It seems that pre-conditioning of exercise can be effective in reducing the degree of degradation of brain tissue due to the use of silver nanoparticles.