Effrct of Tranexamic Acid on the Bleeding of Femoral Rracture in Orthopedic Surgeries

Orthopedic surgeries are associated with a high bleeding and need for blood transfusions. Tranexamic acid is a drug used to reduce bleeding during surgery. The aim of this study was to evaluate the effect of tranexamic acid on bleeding caused by femoral fracture surgery.

In this clinical trial study, 90 patients with femoral fractures who underwent open surgery were studied. Demographic variables such as age and sex and clinical variables such as hemoglobin and bleeding before and after surgery were recorded in patients.

In terms of hemoglobin changes, in the control group who did not have intraoperative blood transfusions, hemoglobin decreased by 1±68.34 mg / dL before and after surgery and in the case group, thisamount decreased by0±91.31 mg / dL. This difference between case and control groups was statistically significant (p <0.001). Preoperative and postoperative hemoglobin in patients without intraoperative blood transfusion was 12±2.91 and 10±8.89mg / dL, respectively (p <0.001) and in patients with intraoperative blood transfusion were 11±37.59 and 9±83.63 mg / dL, respectively (p <0.001). The amount of bleeding during surgery in the control and case groups was 513.12±78.74and 325.11±68.08 (p <0.001), respectively, and the amount of bleeding in 6 hours after surgery in the control and case groups were ml, respectively. It was 36.9±22.6 and 22.89±8.95(p <0.001). Mean bleeding during 6 hours after surgery between case and control groups in different age groups and between the sexes was assessed. The difference between case and control groups was significant in terms of different age groups and between the two sexes.

According to this study, tranexamic acid has beneficial effects in reducing bleeding and reducing the rate of intraoperative blood transfusion in patients undergoing femoral fracture surgery .