Therapeutic and Prophylactic Effects of Curcumin on Acute Hepatotoxicity Induced by Mebendazole Administration in Anti-narcotic Police Dogs (German shepherd)

The aim of this study was to evaluate the therapeutic and prophylactic effects of curcumin on acute hepatotoxicity induced by mebendazole administration in German Shepherd dogs. In this study, 20 dogs were randomly divided into 4 groups. Group A dogs received daily 150 mg / kg of mebendazole orally and in a gelatin capsule with food. Group B dogs received daily 500 mg / kg curcumin and 150 mg / kg mebendazole orally and in gelatin capsules with food. Dogs in groups C and D were treated similar to group 2, except that they received curcumin 2 and 24 hours after taking mebendazole, respectively. ALT, AST, ALP and LDH enzymes were measured in all groups. In group A dogs, serum concentrations of ALT, AST, ALP and LDH enzymes increased significantly after 24 hours (P <0.05). Enzyme levels decreased in groups B, C and D but their effect were significant only in group D and the concentration of enzymes was in the normal range (P <0.05). The results of this study showed that curcumin has significant therapeutic effects against acute hepatotoxicity due to mebendazole administration.