The effect of a moderate-intensity interval training on the plasma levels of LDL receptor-related protein-1 (LRP1) and cerebral and plasma levels of amyloid beta in induced Alzheimer's rats

Deposition of amyloid beta (Aβ) in the brain triggers Alzheimerchr('39')s disease. The aim of the present study was to investigate the effect of moderate-intensity interval training the plasma levels of LDL receptor-related protein-1 (LRP1) and cerebral and plasma levels of amyloid beta in induced Alzheimerchr('39')s rats.

For this purpose, 30 eight-week-old Wistar rats with an average weight of 191±10 g were randomly divided into three equal groups: Aβ+exercise, Aβ, and the control group. The rats of the first and second groups became Alzheimerchr('39')s by injecting Aβ1-42 into the intraventricular space. After three days of recovery, the Aβ+exercise group experienced moderate-intensity intermittent aerobic exercise for four weeks. The other groups continued their normal lives.

The results of one-way analysis of variance showed that there was a significant difference between the average levels of hippocampal Aβ, plasma Aβ, and plasma LRP1 in different groups (p=0.001). Also, the results of LSD post hoc test showed the greatest difference between the mean of Aβ+exercise group and Aβ group in the above variables.

In summary, the results of the present study indicated that the moderate-intensity interval training can increase the plasma levels of LRP1 and environmental clearance of Aβ levels in the hippocampus, resulting in the modulation and control of factors affecting Alzheimerchr('39')s disease in laboratory rats.