Effect of Vitamin D Administration on Glycemic Control inPatients with Type II Diabetes Mellitus and Vitamin D De-ficiency

The prevalence of diabetes mellitus (DM) and its morbidity and mortality are prominent all overthe world. Observational data suggest that vitamin D deficiency is associated with insulin resistance. In thisstudy, we aimed to assess this association.

This study was a clinical trial consisting of 42 patientswith type 2 DM who had vitamin D deficiency. The patients underwent vitamin D replacement with vitaminD pearls (50,000 iu) weekly for 10 weeks. The level of low-density lipoprotein (LDL), high-density lipoprotein(HDL), cholesterol (Chol), triglycerides (TG), hemoglobin A1c (HbA1C), 2 hour post prandial (2HPP), fastingblood sugar (FBS), body mass index (BMI), blood pressure (BP), and 25oHVitD3 were measured before and afterthe treatment in all patients. Data were analyzed with paired t test.

100% of patients reached acceptablevitamin D level (above 30 mg/dl). No toxicity was reported. Changes in FBS, 2Hpp, HbA1C, Chol, SBP weresignificant and there was no significant change in LDL, HDL, and DBP.

Screening for vitamin Ddeficiency and its replacement may have a beneficial effect on type 2 DM management and its associated riskfactors. More studies with larger sample size and use of placebo are recommended.