Does intravenous ibuprofen have an effect on pain control and drug use after upper limb orthopedic surgery? A double-blind randomized clinical trial Study

Pain after surgery is an unpleasant experience. This process causes physiological disorders in all systems of the body.

In this randomized double-blind clinical trial study, 60 patients with anesthesia class I and II underwent upper limb orthopedic surgery. Patients were randomly divided into intravenous and control ibuprofen. Systolic and diastolic blood pressure, mean arterial pressure and heart rate before surgery, 1, 10 and 20 minutes after surgery were recorded. Pain was measured before, 6, 12 and 24 hours after surgery.

Ibuprofen and control groups were similar in terms of gender, age, BMI and ASA. The results of Chi-square test showed that in recovery and 6 and 12 hours after surgery, pain in patients in the ibuprofen group was significantly less than the control group (P <0.05). Also, the intragroup pain trend was significant in ibuprofen and control groups (P <0.05). Mean pain in ibuprofen group decreased more than control (P <0.001).

The results of the present study showed that intravenous ibuprofen is better in controlling pain intensity and drug use than the control group. Ibuprofen seems to be very effective in controlling pain and postoperative drug use in orthopedic surgeries.