A Review on Antioxidant-rich Products as Protective and Therapeutic Agents Against Chlorpyrifos Hepatotoxicity

Recently, the growing attention of the scientific community has been focused on the threat to health created by environmental pollutants, including pesticides such as chlorpyrifos (CPF), and on the need of finding effective ways to treat and prevent the unfavorable health effects of exposure to them. Particularly promising for CPF, and thus arousing the greatest interest, is the possibility of using various ingredients present in plants, including mainly polyphenol compounds. As the liver is one of the organs for this pesticide and disturbances in the proper functioning of this organ have serious consequences for health, the aim of the present review was to discuss the possibility of using polyphenol‐rich food products as the strategy for the protection against this xenobiotic hepatotoxicity and treatment of this pesticide‐induced liver damage.

A comprehensive search was performed in various databases using specific keywords such as "biologically active compounds", "antioxidants", "Chlorpyrifos/CPF", "environmental exposure", "health effects", "hepatotoxicity", "liver damage", "mechanisms of Chlorpyrifos/CPF action", "oxidative stress", "preventive strategies", "polyphenols", "protection", "risk for health", and "treatment".

Due to the ability and the strong antioxidative potential of polyphenols, as well as their abundance in dietary products, it seems to be of high importance to consider the possibility of using polyphenols as potential preventive and therapeutic agents against CPF hepatotoxicity, determined by its strong pro‐oxidative properties. Although most of the data on the effectiveness of polyphenols comes from studies in animals, the fact that some of them are derived from experimental models reflecting human exposure to this pesticide allows us to assume that some polyphenol food products may be promising protective effect against CPF hepatotoxicity in humans.