Comparison of Pulmonary Function in Patients with Cystic Fibrosis Before and After Bronchoscopy

Cystic fibrosis (CF) is one of the most common life-limiting recessive genetic disorders in, caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). CF is a multi-organ disease that involves the lungs, pancreas, sweat glands, digestive and reproductive systems and several other tissues. This debilitating condition is associated with recurrent lower respiratory tract bacterial and viral infections, as well as inflammatory complications that may eventually lead to pulmonary failure. The aim of this study was to compare the pulmonary function of patients with cystic fibrosis before and after bronchoscopy.

This study was performed on 18 patients with cystic fibrosis (children and adults) who were admitted to Masih Daneshvari Hospital (Tehran, Iran). Spirometry was performed before and after bronchoscopy and pulmonary lavage. Forced vital capacity (FVC) and Forced expiratory volume in the first second (FEV1) were evaluated. These criteria were compared before and after bronchoscopy.The mean age of patients was 15.2 years, ranging from 5 to 24 years. FVC was less than 60% in most patients (66.7%) and only 33.3% of patients showed normal or mild respiratory dysfunction. However, in the statistical analysis performed, probably due to the lack of samples, no significant increase was seen in the FVC after the intervention; But the FVC clearly increased. The FVC rose from an initial average of 56.77٪to about 57.27٪. (pvalue: 0.033). FEV-1 rose from an initial average of 47.27% to about 54.50%. (Pvalue:0.01)