The effects of fish oil omega-3 on asthma induced by albumin in male albino rats

This study was designed to evaluate the levels of some biomarkers, including Galectin-3, Periostin, and Interleukin-33 in male albino rats induced as asthma disease model using albumin extracted from the egg. In addition, the histological and physiological indices were investigated to reveal of the protective role of fish oil (omega -3) (2-4mg/kg of body weight) against asthma induced by albumin for four weeks. These biomarkers are new diagnostic biomarkers for asthma-induced disease by albumen extracted from the egg and aluminum hydroxide. For this purpose, forty male albino rats were treated during 2020 to December 2020. The experimental animals are divided into four groups included: (1) treated group: ten animals for one month administrated with 2mg/kg omega-3, (2) 10 animals for one month administrated with 4mg/kg omega-3, (3) asthma induced group with 10 animals, and control group 10 animals. The results showed significant increases in serum concentrations of Galectin-3, Periostin, and Intrleukin-33 in induced asthma albino rats group (P<0.05), while there was a significant decrease in serum concentrations of Galectin-3, Periostin, and Interleukin-33 in the groups which treated with omega-3 fish oil as compared with induced asthma albino rats group (P<0.05). The histological sections of albino rats’ lungs revealed asthma induction in lung tissue which represented by degeneration, necrosis and high amount of the mucous production in bronchioles as well as infiltration of inflammatory cells around bronchioles while effects of albumin in bronchi and trachea sections showed sloughing, degeneration and necrosis around the epithelium of bronchioles. Based on the results, fish oil omega-3 has improved most histological and physiological deterioration.