Correlation of vaspin levels with anthropometric and biochemical parameters in patients with Non-alcoholic fatty liver disease in an Iranian population

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease. The NAFLD is associated with obesity, insulin resistance, and dyslipidemia. Vaspin is a newly discovered adipokine that has several functions, including regulation of carbohydrate and lipid metabolism. This study aimed to investigate the relationship of vaspin levels with NAFLID as well as anthropometric and biochemical parameters.

This case-control study was conducted on a total of 150 participants who were divided into the case (with NAFLD; n=75) and control groups (n=75). The serum levels of vaspin and insulin were measured by ELISA kit, and other variables were determined by standard methods.

There was no significant difference between the patients with NAFLD (grades 1, 2, and 3) and healthy controls (P>0.05) in terms of vaspin levels. Moreover, the patients with NAFLD had significantly higher body mass index, levels of transaminases, triglycerides, systolic blood pressure, insulin, and insulin resistance, compared to the control group (P<0.05). In this study, an inverse correlation was observed between vaspin and diastolic blood pressure with cholesterol (P<0.05). However, no association was found between vaspin and lipoproteins, as well as insulin resistance and liver enzymes (P>0.05).

The findings showed no relationship between vaspin and NAFLD. However, serum vaspin levels are correlated with cholesterol levels and diastolic blood pressure (in all subjects).