The Effects of 8 Weeks Aerobic Exercise Training on Serum levels of Myonectine and Insulin Resistance in Obese and Overweight Women

Obesity is associated with cardiovascular disease, metabolic syndrome and diabetes, and insulin resistance. Myonectin is a type of myokine that has a high rate of secretion in skeletal muscle and is inversely related to obesity. This study aimed to investigate the effect of 8 weeks of aerobic exercise on myonectin levels and insulin resistance in obese and overweight women. In the present study, 21 overweight and obese women participated as subjects, who were divided into two groups of exercise and control. The exercise program was performed for 8 weeks, which included three sessions of aerobic exercise per week, each session lasting 30 minutes with an intensity of 50 to 70% of the maximum heart rate. The maximum heart rate in exercise was 50% in the first two weeks, 60% in the second two weeks, 65% in the third two weeks, and 70% in the last two weeks. Blood sampling was drawn 48 hours before the start and 48 hours after the last training session and serum levels of mayonectin, glucose, and insulin were measured. Analysis of covariance was applied to examine the differences between groups by using IMB SPSS v.21 software. Serum levels of myonectin increased in the exercise group compared to the control group, but this amount was not significant (P=0.08). Furthermore, the level of insulin resistance in the exercise group compared to the control group was significantly reduced (P=0.006). Based on the results, aerobic training led to an increase in serum levels of myonectin and a decrease in insulin resistance in the subjects of this study. It can be concluded that due to the role of mayonectin in increasing the absorption of fatty acids, aerobic exercise can play a significant role in reducing obesity-related diseases and metabolic syndrome, which according to the current results, this effect is relatively associated with the role of mayonectin.