Effects of Beclomethasone and Adcortyl in the treatment of Erosive Oral Lichen planus lesions: A Comparative Study

Lichen planus (LP) is a common chronic immune-mediated mucocutaneous disease, the exact cause of which is unknown. One of the common treatments for erosive lichen planus (ELP) is the use of topical corticosteroids of adcortyl ointment (triamcinolone in orabase). On the other hand, beclomethasone spray as a topical corticosteroid is easy to use in the mouth. The purpose of this comparative study was to investigate the effects of beclomethasone and adcortyl in the treatment of erosive oral lichen planus lesions (EOLP).

The present single-blind clinical trial was conducted on 50 patients with EOLP lesions with a mean age of 40.55 years at Jondishapur University of Medical Sciences, Iran. Beclomethasone and adcortyl were co-administered on lesions in both sides of the mucosa of the cheek, gums or margin of tongue for 3 to 6 weeks, after which the dose was adjusted. Visual analogue scale was used to evaluate the effect of drugs. Data were analyzed by paired t-test, Wilcoxon and Kolmogorov-Smirnov tests (α = 0.05).

The results of this study showed that there was no difference between applying beclomethasone and adcortyl in terms of reducing the extent and severity of EOLP lesions, and adcortyl was more effective than beclomethasone in relieving pain symptoms (P < 0.05).

The therapeutic effects of the adcortyl and beclomethasone were similar in controlling the EOLP lesions. Adcortyl was more effective than beclomethasone in relieving pain and irritation symptoms.