Impact of Quercetin on Sperm parameters, Testicular Tissue, and Sex Hormone: A Systematic Review

Quercetin is a polyphenolic flavonoid compound with a potent antioxidant impact, proposed to make a drastic contribution in treating male infertility. The current systematic review aimed to provide an overview of previous studies about quercetin's impact on male infertility.

Electronic search with MeSH words including Quercetin, Infertility, Sperm, Testicular tissue, and Sex hormones was accomplished in databases Web of Science, Scopus, Science Direct, Wiley, NCBI, and Google Scholar. Finally, 296 articles were recognized during the primary search. A total of 144 papers,passing the analysis stage containing Identification, Screening, and Eligibility were selected for assessment.

Quercetin prevents damage to the testicular germinal epithelium and facilitates the spermatogenesis process by strengthening the antioxidant system, reducing lipid peroxidation and oxidative stress, preventing the expression of pro-apoptotic genes, increasing testosterone and gonadotropins.

In conclusion, the present review showed that quercetin by its antioxidant impacts, can counteract various toxins that induce oxidative stress in the male reproductive system.