Evaluating Oxidant and Antioxidant Determinants in Febrile Seizure Patients Hospitalizing at Karaj’s Bahonar Hospital

Febrile seizure is one the most common pediatric disease. Diagnosis of this disease is usually based on the history and clinical signs and symptoms. Various factors have been suggested as pathogenesis of febrile seizure but the main cause is still unknown. Recent studies recommended a relationship between oxidative stress and febrile seizure. This study aimed to examine the relationship between febrile seizure and Malondialdehyde (MDA) serum level as an oxidant determinant and Superoxide dismutase (SOD) serum level as an antioxidant determinant.

In this case-control study, two groups of people including 46 patients with simple and complex febrile seizure, and 44 normal children were studied. There was no history of febrile seizures, afebrile seizures, epilepsy or any types of neurologic and metabolic disorders in patients. Thus, serum levels of MAD and SOD in the two groups of study were evaluated, separately.

The findings of this study showed a significant increase in malondialdehyde enzymes compared with healthy subjects. Also, the results of the measurement of the superoxide dismutase enzyme indicated a significant increase compared to the healthy group.

Significant increase in SOD and also a significant increase in MDA may be due to the stimulation of compensatory responses in the brain and subsequent the antioxidant system counteracting the oxidant system. These results also indicate the importance of time for enzyme measurements.