Application of Polyurethane in Drug Delivery System

The feld of drug delivery is a very hot research area as it afects the life of millions of patients every year. Although pharmaceutical agents can be adminisrated in diferent ways, the efectiveness of certain drug delivery sysem (DDS) is directly related to the method of their adminisration. Polyurethanes are one of the mos important classes of polymers, that play an essential role in the development of many diferent biomedical devices due to their exceptional compatibility, mechanical properties and fexibility. Polyurethanes are formed by the reaction reviewed of isocyanates and diols to produce urethane-bonded polymers (-NH-COO-) in their main chain, which is similar to the peptide bonds in the sructure of proteins. Because of this similarity, they have also been used as part of the human body, such as dialysis membranes, intra-aortic balloons, heart valves, temporary scafolds and breas implants. There are many types of polyurethane sructural blocks available that allow the chemical and physical properties of polyurethane to be tailored to their intended applications, especially in the medical and pharmaceutical felds. In this paper, the synthesis and properties of polyurethane, sructure, thermal sability, hardness, solvent resisance, drug delivery, mechanical properties as well as biodegradability and biocompatibility with special emphasis on the application of the polymer in controlled release of drugs and delivery to the target tissue were.