In this research, a model for Entrepreneurship University based on future skills and jobs has been developed and validated. The research method in this article was mixed model research that based on grounded theory (by interviewing 20 experts in the field) and the quantitative method based on questionnaire taken from the indicators of the qualitative stage and based on valid 385 questionnaires. The research findings in the qualitative part showed that this model has 6 outcomes and 20 components. This set includes the "Entrepreneurial University for Future Skills and Careers", "Causal Conditions", "Background Conditions", "Intervention Factors", "Strategies" and "Consequences and Outcomes". The findings of the quantitative part also showed that factor loads of all indicators were higher than 0.4. The goodness indicators of the model fit also showed that the relative chi-square index value is less than 3 and the Adjusted Goodness of fit index (AGFI) and the adaptive fit index (CFI) have been above 0.7. The root mean square error approximation (RMSEA) was also less than 0.1.  Therefore, such a model has a good explanation in the statistical population. As a result, we can say that the University of Entrepreneurship can invest in future skills and work in developing and promoting entrepreneurship and retraining skills in order to carry out future activities. Therefore, creating a fundamental and structural change in other cases and pillars of the country's universities in order to move towards entrepreneurship based on future skills and work will cause the growth and development of the country.